…is the remedy for people who have reached the limits of endurance.
They have explored all avenues and see no way out of their difficulties. They feel there is nothing left for them but annihilation and emptiness.
For those moments which happen to some people when the anguish is so great as to seem to be unbearable. When the mind or body feels as if it had borne to the uttermost limit of its endurance, and that now it must give way. When it seems there is nothing but destruction and annihilation left to face.
– The Twelve Healers and Other Remedies